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Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery

Purpose

This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energy x rays to kill tumor cells. It is not yet known whether comprehensive radiation therapy is more effective than standard radiation therapy in treating patients with breast cancer

Arms Assigned Interventions

Active Comparator: Group 1A Lumpectomy: no regional nodal XRT with WBI

Lumpectomy patients undergo whole breast radiation therapy using IMRT or 3D-CRT once daily 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks.

Radiation: WBI

Other Name: Whole Breast Irradiation (WBI)

No Intervention: Group 1B Mastectomy: No regional nodal or chest wall XRT

Mastectomy patients do not undergo radiation therapy.
 

Experimental: Group 2A lumpectomy: Regional nodal XRT with WBI

Lumpectomy patients undergo regional nodal radiation therapy with whole breast radiation therapy using IMRT or 3D-CRT once daily 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks.

Radiation: regional nodal XRT

Other Name: XRT: External radiotherapy

Other Name: Whole Breast Irradiation (WBI)

Experimental: Group 2B Mastectomy: Regional nodal XRT and chest wall XRT

\Mastectomy patients undergo regional nodal radiation therapy using IMRT or 3D-CRT once daily 5 days a week for 5 weeks.

Radiation: regional nodal XRT

Other Name: XRT: External radiotherapy

Radiation: chest wall XRT

Other Name: XRT: External radiotherapy
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