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Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer

Radiation therapy uses high-energy x-rays to kill tumor cells. Radiation therapy may cause skin reactions when patients are exposed to high-energy x-rays. Studying the genetic pattern of patients before and after radiation therapy may help doctors prevent toxicity and plan the best treatment.

This clinical trial studies genetic susceptibility to radiation-induced skin reactions in racial/ethnic groups of patients with breast cancer. This is a multicenter study for patients undergoing adjuvant radiotherapy after breast-conserving surgery.

Blood and urine samples are collected at baseline and last day of radiotherapy. Patients are assessed for acute toxicity by research staff at baseline, week 3, and at 1 and 2 months after radiotherapy. Patients are also assessed for chronic toxicity by research staff at 6 and 12 months after completion of radiotherapy. Patients will be asked to complete the questionnaires at baseline, last day of radiotherapy, and at 1, 2, 6, and 12 months after radiotherapy.

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